The opiate antidote naloxone has been saving lives since Jack Fishman discovered it in 1961. This ornate design has the text' Naloxone, saving peoples lives since 1961, overdose prevention, rock it' (note: this is also available as a duvet!)
Naloxone is the opiate antagonist that can reverse overdoses, in some areas though it's known by the brandname Narcan. This T-Shirt uses the popular 'Keep Calm' meme to point out the importance of carrying this life saving medication.
Sara McGrail gave an amazing keynote at the 2012 Hot Topics conference, the quote reads "If harm reduction is out of fashion, then to hell with fashion! Harm Reduction is as relevant, and possibly more important, than it has ever been before."